The History of the B Vitamins

The history of the B vitamins is a fascinating journey that spans several decades and involves the work of numerous scientists. Initially thought to be a single nutrient, it was later discovered to be a complex group of essential water-soluble vitamins with distinct functions. Here's a brief overview of their discovery:

The Beriberi Connection

The story begins in the late 19^th Century with the investigation of beriberi, a debilitating disease prevalent in regions where polished white rice was a dietary staple.

• 1889: Dutch physician Christiaan Eijkman, working in the Dutch East Indies (now Indonesia), observed that chickens fed polished white rice developed beriberi-like symptoms, which were reversed when they were fed unpolished brown rice. This suggested a nutritional deficiency.
• 1906: English biochemist Frederick Gowland Hopkins proposed the existence of "accessory food factors" beyond fats, proteins, and carbohydrates that were essential for growth and health.

The “Vitamine” Concept

• 1911: Polish biochemist Casimir Funk, working in London, isolated a substance from rice polishings that could cure beriberi in pigeons. He proposed that this and other similar substances were vital amines, coining the term “vitamine.” Although not all vitamins are amines, the name stuck (later dropping the “e”).

Distinguishing Multiple Factors

• 1913: American biochemist Elmer McCollum distinguished between “fat-soluble factor A” and “water-soluble factor B,” recognizing that there was more than one essential nutrient in the water-soluble category.

Isolation and Identification of Individual B Vitamins:

The subsequent decades saw the isolation and characterization of the individual B vitamins:

• Vitamin B1 (Thiamin): Isolated in crystalline form in 1926 by Dutch chemists Barend Jansen and Willem Donath. It was the first B vitamin to be identified and was found to be the anti-beriberi factor.
• Vitamin B2 (Riboflavin): First observed as a yellow-green fluorescent pigment in milk in 1872, it was characterized and named riboflavin in the early 1930s.
• Vitamin B3 (Niacin): Its deficiency was linked to pellagra in 1915 by Joseph Goldberger. The chemical structure was determined in 1937 by Conrad Elvehjem.
• Vitamin B5 (Pantothenic Acid): Discovered in 1933 by Roger J. Williams while researching essential nutrients for yeast.
• Vitamin B6 (Pyridoxine): Identified in 1934 by Paul Gyorgy.
• Vitamin B7 (Biotin): Research spanned the early 1900s, with contributions from Margaret Averil Boas (1927) and Paul Gyorgy (who named it Vitamin H in 1939), among others.
• Vitamin B9 (Folate/Folic Acid): Identified in 1933 by Lucy Wills for its role in preventing a type of anemia during pregnancy.
• Vitamin B12 (Cobalamin): Its deficiency was linked to pernicious anemia. It was isolated in 1947 by Karl Folkers and his team.

The “B Complex”

As each water-soluble vitamin with a distinct function was discovered, they were grouped together as the “vitamin B complex.” This term reflects their shared water solubility and their common occurrence in many of the same foods, as well as their often-interconnected roles in metabolic processes.

Nobel Prizes

The importance of B vitamin research is highlighted by the Nobel Prizes awarded to scientists involved in their discovery and understanding:

• 1929: Christiaan Eijkman and Sir Frederick Gowland Hopkins were jointly awarded the Nobel Prize in Physiology or Medicine for their work on the discovery of vitamins. Eijkman's work focused on the link between diet and beriberi (leading to the identification of Vitamin B1), while Hopkins was recognized for his broader contributions to the understanding of essential nutrients.
• 1934: George Whipple, George Minot, and William Murphy received the Nobel Prize for their work on the treatment of pernicious anemia using liver extracts, which eventually led to the isolation of Vitamin B12.
• 1964: Dorothy Hodgkin was awarded the Nobel Prize in Chemistry for her work on determining the structures of important biochemical substances, including Vitamin B12.

Modern Understanding

Today, we have a detailed understanding of the chemical structures, functions, dietary sources, and deficiency symptoms of each of the B vitamins. They are known to play crucial roles as coenzymes in numerous metabolic pathways, affecting energy production, nerve function, red blood cell formation, DNA synthesis, and many other vital processes.

It's worth noting that several other substances were once considered part of the B complex and assigned B numbers (like B4, B8, B10, B11), but these were later found to be either synthesized by the body or not essential and were thus removed from the official list of B vitamins

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William Garst is a consultant pharmacist who lives in Alachua, Florida. He is semi-retired and works part time at Lake Butler Hospital in Lake Butler, Florida. William received his pharmacy degree at Auburn University and a Doctor of Pharmacy from Colorado University. The Pharmacy Newsletter is a blog where you can find other informative columns. He may be contacted at garstcph@gmail.com.

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