ALACHUA – Daily insulin injections can be a hassle for people with diabetes. Those who dislike needles might have a reason to rejoice, though. In about four years, one company from Alachua hopes to market a new way to deliver injectable drugs such as insulin that doesn't require daily needle injections.

Prometheon Pharma, based out of the Sid Martin Biotechnology Incubator, is developing a patch capable of delivering a wide range of medicine through the skin, similar to a nicotine or estrogen patch.

“I think it has a potential to completely change people’s lives,” said Dr. Stephen Hsu, founder and CEO of Prometheon.

Prometheon aims to make their extended-wear Topiconpatches capable of delivering a consistent dosage of medication for up to seven days. Somebody could put it on one Sunday and change it the next, Hsu said. It would also be more efficient for delivering medication that is metabolized by the liver, he said. When somebody takes oral medication, a significant fraction of the drug could be eliminated by the liver before the drug has a chance to enter the bloodstream. About 40 to 50 percent of insulin normally produced by the pancreas of healthy people is immediately metabolized by the liver.

Hsu believes the patch has a diverse potential beyond delivering just injectable drugs. It could be used to deliver vaccines, chemotherapy or anti-depressants, for instance.  

“We don’t know what the limit of what we can do is,” he said, pointing to gene therapy as one other possible application.

“When you’re depressed, it takes you two hours to get out of bed and brush your teeth, let alone take your drugs,” Hsu said. By making treatment easy and convenient, he believes more people will take and benefit from their medications.

Non-compliance with taking prescribed medication is a huge problem in healthcare, he said. For people with diabetes, only about 60 percent of prescribed injections are actually done, he said.

“It’s inconvenient, it’s painful, it's easy to forget” Hsu said. “People hate needle injections. The convenience of a simple patch will lead to higher compliance.”

Prometheon decided to tackle insulin as the first application of the patch.

“We have this huge global epidemic of obesity and diabetes,” Hsu said, making the choice of which drug to first utilize the patch for obvious.

Unlike injectable insulin, the TopiconDM insulin patch would not need to be refrigerated, improving access to the medicine in developing countries without reliable electricity or refrigeration. The medicine is stored on the patch as a solid, but melts into a gel only when warmed by the wearer’s body temperature. Hsu is working on a heat-resistant patch for use in much warmer climates.

The company is making every effort to make all Topicon patches biodegradable and eco-friendly, he said. Any remaining medicine in the patch can be rinsed off with hot water in the sink so that the drug-free patch can be safely discarded.

“There are stories of children who pick their parents' discarded patches out of the garbage,” Hsu said. “The children imitate their parents and put the patch on, and then they die.”  

The problem in the past with getting a patch like this to work has been that the molecules for most medications are too large to be absorbed through the skin, he said. Hsu said he has found a way to make it work, but cannot go into detail while the patent is still pending.

Prometheon has already tested the Topicon DM patch on diabetic rats with success, he said. The next step is using pigs. Because it is a delivery device for already FDA-approved drugs and generics, the regulatory approval process will be much shorter than it is for bringing a new drug on the market.

Hsu plans on the patch being on the market in early 2018. He believes the improved access to affordable vital drugs and convenience of the product will bring about a healthier world.

“Ultimately, that translates into better quality of life,” he said.         

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W - RC Park option 1NEWBERRY – David Wallace became interested in remote-controlled vehicles last February with some of his fellow employees at the City of Newberry.

“It was just so engrossing, the hobby itself, the people you meet, all the different aspects—I just got overwhelmed with it,” said Wallace, lead operator for the city’s wastewater treatment plant.

But it turned out there was no place in Newberry for them to come together and race the remote control vehicles.

“We were looking for something local, because you either have to go to High Springs or Ocala,” said Jason McGehee, another remote control enthusiast and creator of an online forum for the city.

Wallace and the newly formed remote control club approached Richard Blalock, Newberry’s parks and recreation department director.

They discussed possible options for building a remote control track, and the space by the retention pond by Easton Newberry Sport Complex’s baseball fields seemed to be a good location.

Now that Easton just got its Community Olympic Development Program designation, the remote control track idea would be a great way to bring more people in, McGehee said.

“Richard pretty much said ‘Hey if there’s going to be a big interest I have no problem with it, but you are going to have to come up with your own funds,’” Gehee said.

Wallace took the reins and got the idea off the ground financially as he and his friends spent their weekends hauling dirt to build a temporary track. It took eight days in early May to finish.

After the track was put together, the group got in touch with Eric Canto of Hobbytown USA in Gainesville to invite the public to try out the track and gage how many people were interested. About 200 people came.

“I never knew that this hobby is as big as it is,” McGehee said.

About 10 to 15 people come out on Sundays to utilize the track and fly remote control planes and helicopters. The FaceBook page, Friends of the Newberry Remote Control Park, posts pictures and videos from the high-definition cameras attached to the planes or helicopters.

At first the remote control club used city equipment, since many participants worked for Newberry, but once the club aimed to have a permanent track as well as an official space for flying vehicles, it had to explore funding options.

Wallace received an email from the city’s utility director detailing an available grant of $50,000 that would be appropriate for the remote control park venture. There was no requirement to match the amount in the application process.

A resolution in favor of applying for the grant passed the city commission on Sept. 9.

In order to be eligible to apply for the grant, the interested party must have a functioning official board. The Newberry remote control park board includes President Eric Canto, long-time racer, and Tracy Carver, the vice president and treasurer. Miguel Marandez, secretary, Jason McGehee and Alan Wight, as a special consultant, are also members.

As for recruiting, McGehee and Wallace wanted another person on board who was “all about Newberry,” Wallace said.

“Whatever our goals are, we want to put Newberry out there first and foremost,” he said.

The board has an account set up to accept donations, and has already received some incoming money.

The permanent high-bank dirt oval racing track is now finished and open for practice runs. If all goes according to plan, the club will upkeep the old track by the retention pond as a rally course for beginners. There will also be an off-road track for club racing to provide for weekly or summer racing events.

A large outdoor flying facility is also part of the club’s vision for the remote control park, and Easton already has the space to accommodate indoor flying and racing in the gym.

“So basically Newberry will have everything for remote control except water,” Wallace said.

“But everything else, we’ve got covered,” he said.

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W - literacy dayHIGH SPRINGS – Silver Sovereign, the snow-colored, blue-eyed newly born horse will be making his public debut at O’Leno State Park soon.

The foal, whose barn name is Little Prince, was born the same day and time as the new prince in England. At only 14 inches at birth, he is one of the smallest foals born at Gentle Carousel, a company which breeds horses for therapy. He and his mother, Liberty, will be visiting with kids for a short time early in the day Saturday, Sept. 7 as part of the “Where Tales Meet Trails” event at the O’Leno State Park.

The event runs from 10 a.m. to 2 p.m.

“This will be his first outing,” said one of Little Prince’s owners, Debbie Garcia-Bengochea. “He can only stay a short time because he is so young,” she said.

Children of all ages are invited to the annual event on the grounds of O’Leno State Park, six miles north of High Springs on U.S. Highway 441. Book authors, storytellers and book illustrators will be there, along with games for the visitors to play.

Admission is free by showing a library card, library book or by donating a new or gently used family-appropriate book. Some of the donated books are given out during the festival as prizes, said event coordinator, Cynthia Preston, O’Leno Park Service specialist.

The event is designed to promote literacy and spark an interest in reading among young people.

Any books left over are given to Gentle Carousel to leave with children as they visit children’s hospitals and rehabilitation centers around the country.

Garcia-Bengochea is just one of the authors who will be on hand to read the books they’ve written. Gentle Carousel’s award winning literacy program, Reading is Magic, brings real miniature horses dressed in appropriate character costumes to help illustrate stories for the children in an effort to bring books to life for them.

Each reader has their own booth spread out around the pavilion in the picnic area. Park volunteers will have games set up in the picnic area near the river for kids to enjoy, Preston said. A bean-bag toss and a book walk, similar to a cake walk, but with the prize of a book, will be just some of the games children can expect.

Park volunteer Ann Dominy will lead an adventure walk, where children stop and read sections of a book at certain points in the walk.

Another highlight for older children and adults will be a visit from Valerie Rivers, park manager at Marjorie Kinnan Rawlings State Park. She will be reading excerpts from “The Yearling” in honor of the 75th Anniversary of its publishing. She will be reading in the pavilion and also will have her own booth for those who would like to visit and learn more.

Author and book illustrator Sandra Poucher, who has written “The Taming of the Slough,A Field Guide to the Critters of Florida's Springs” and “Speleological and Karst Glossary of Florida and the Caribbean” will be sharing some of the drawings she did for her books and will work with children to do illustrations of their own.

High Springs’ resident Diane Eastman will be dressed as Mother Goose and will be reading stories to children in her booth. Other High Springs readers will be Nancy Habig and Linda Lenseth, from Sally’s Sensibles in High Springs. “They always decorate their booth to illustrate the book they are reading,” Preston said. “They are a lot of fun and have been doing this for children for several years.”

Also, High Springs librarian Beth Noll will be one of the readers this year.

Linda Williams and several other ladies from the Daughters of the American Revolution will be reading excerpts from historical novels about the Revolutionary War.

Friends of O’Leno will have an information booth set up with cookies and drinks for everyone. For those who want more than a snack, Jeff Runde, from Branford, will have hot dogs and drinks for sale.

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HIGH SPRINGS – Damon Messina has a busy schedule. Aside from being the assistant recreation director in Alachua, he is also a part-time coordinator of parks and recreation activities in High Springs.

Now, the City of High Springs has decided to hire a full-time coordinator who can build up the city’s recreation programs.

“He does a great job, but he also has a full-time job,” City Manager Ed Booth said of Messina. “We need somebody now who will take it to the next step.”

The city commission met Thursday, Sept. 5, where Booth presented the proposal for adding the position to this year’s budget. The motion to add the job passed 4-1, with Commissioner Linda Clark Gestrin opposing it.

Gestrin said she felt it wasn’t a good time to hire somebody for the position, but she didn’t oppose the general idea and might be receptive to it in the future. For now, the city should focus on basic services like police and the fire department, she said.  

The position would pay around $31,000 a year with around $12,000 in benefits, according to the proposal Booth presented, but that isn’t set in stone. There will be negotiations with the candidates.

“It depends on the person’s qualifications,” Booth said.  

The coordinator for parks and recreation activities would have flexible hours, he said. About 32 hours per week would likely be spent overseeing sports programs, making sure the tennis courts, fields and playgrounds are maintained and managing the community center. About eight hours each week would probably be spent managing the farmers market. The coordinator would have to work some evenings as well. Part of the job would be managing the grants to renovate the sports facilities in the city and organizing activities for children, teens and young adults.

“I’m looking for somebody who is very energetic,” Booth said.

Having a full-time coordinator for parks and recreation activities will increase the quality of life for High Springs’ citizens, he said.

“A city is more than streets, sewer and water,” Booth said.

The next step in the process is presenting a job description to the recreation board. Booth hopes to begin searching for a candidate in November or December and hire somebody soon after.

 

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W - Easton Olympic Rings DSC 1330NEWBERRY – Newberry joined a list of proud cities Friday. That list boasts the likes of New York, Chicago, Atlanta and San Antonio. They did so with the Easton Newberry Sports Complex receiving a Community Olympic Development Program (CODP) status for archery Friday, Aug. 30. The city is one of only 10 in the nation to receive such a designation and only the second of its kind to showcase archery.

“The city earned this designation after almost two years of working towards it and getting a USA Archery endorsement,” said Bobbi Ullman, a United States Olympic Committee representative.

The ceremony took place Friday morning at the Easton Newberry Sports Complex, located at 24880 NW 16th Ave. in Newberry. The junior archers kicked things off with an open shooting session that started at 10:30 a.m.

Around noon, the athletes, their families and some Newberry residents made their way into the gymnasium-turned-ballroom for a luncheon and the CODP presentation.

In attendance at the ceremony were Bobbi Ullman, London Olympic men’s team archery silver medalist Jake Kaminski, Easton Sports Development Foundation vice president, Don Rabska, and Easton Sports Development Foundation president, Greg Easton.

Everyone near the event seemed to be brimming with excitement, but it would be hard to match the enthusiasm that belonged to Robert Turner, head archery coach at the complex.

“To try to explain what this means for our kids is incredibly difficult,” Turner said when asked how this could improve the facility. “This will give every athlete the opportunity to try archery in a professional setting, with top notch coaching, equipment and facilities.”

Turner began his archery career at the age of 15, ending up with five national championships in his native Australia. He worked with the Australian National Team before coming to the Easton Foundation three years ago. He has also been involved with the United States National Team, a relationship that helped to put the small-town complex on the map.

When the luncheon was coming to a close, the attendees were moved back into the room where the first shooting session took place so the wall displaying the CODP logo could be unveiled. The junior archers gathered along the wall with Greg Easton and together pulled the covering off. The consensus among the event-goers seemed to be that it was a rewarding moment for those who worked so hard.

“While this is about establishing an Olympic pipeline, it’s also more than that,” Rabska said. “It brings me joy to see a community come together and earn something like this.”

The excitement of the event was also multiplied with the attendance of Jake Kaminski, a silver medalist at the London Olympics. Kaminski has been a professional for seven years and said he wished he could have had the support from a great facility when he was first beginning in archery.

“For these kids to get proper coaching and get started on the right foot is so invaluable,” Kaminski said.

The Easton Newberry Sports Complex is home for upwards of 200 archers for classes each week said Turner. The students range in experience from first-time shooters to having two or three years already under their belt. On top of being honored with the CODP status, the complex will also play host to the Florida Archery Association Federation of International Target Archery State Championship Sunday, Sept. 8.

The motivation behind the United States Olympic Committee creating the CODP designation is not just to expand the Olympic pipeline but also to provide youths with an opportunity to participate in Olympic sports. Now with even greater support, the community of Newberry will be able to continue to offer a high level of instruction to these athletes, Ullman said.

“Going to London and being with track stars and athletes of all sports, and being able to feel the same, was a dream come true,” Kaminski said. “If this kind of program can help someone make the change to being a professional easier, it will be incredible.”

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W - Diner DSC 1362HIGH SPRINGS – Classic cars conjuring up images of the 1950s filled the lot outside The Diner in High Springs last week during a celebration marking what the new owners hope will be a new era for the restaurant.

On Friday, Aug. 30, The Diner, formerly known as Floyd’s Diner, had its grand reopening from 2 p.m. to 7 p.m. The restaurant was bought in late May by husband-and-wife duo Kim and Jerry Wakefield. Though it didn’t really close down when ownership changed, the reopening symbolizes a fresh start for the restaurant, said manager Beth Citta.

“The reputation we got from the old place is not what it should be,” she said. Now all the changes have been finalized.

The new owners plan to use more fresh ingredients from local farmers. In addition, they are using a new distributor for the rest of the ingredients. Some tweaks to old recipes have been made, and new additions can be found on the menu.

“The buffalo chicken sandwich is our top seller,” Citta said, at least when it comes to the new food choices. The new owners hail from Bishop’s Stortford in England, so they have incorporated English elements into the menu, such as fish and chips.

The consensus from several regulars of the diner seems to be that the quality had dipped in the last six or so years.

Customer John Blaine complained about the previous owner using a scale to measure the precise amount of ingredients he put in Blaine’s sundaes.

“This is a real sundae,” he said during the reopening, when the waiter handed him his treat from across the bar.

The food is just as good as ever with the Wakefields as the owners, but Blaine has noticed he gets larger portions.

“They really are on the money,” he said, noting how they no longer use scales to measure content.

“They hire good people here,” Blaine said. “The service is excellent.”

All day, vintage cars, some for sale, were parked outside the diner to drive home the 1950s motif. At 4 p.m., the classic rock, folk and blues band Moondogs took the stage outside. At 7 p.m., the High Springs police brought in the Blues Brothers Soul Band in a police car, reenacting a scene from their namesake film.

“I’ve seen both of them before,” Blaine said of the bands. “Both of them are excellent.”

The Diner plans to hold music events once a month, manager Citta said.

About 70 people had dined at the restaurant by about 3:30 p.m., but Citta said she was hoping for about 500 people.

Jerry and Kim Wakefield lived in France for the past several years, but decided to move to another country.

“The Euro isn’t doing too well at the moment,” said Jerry Wakefield. “We felt like America was a good place to be.”

They looked at several restaurants in Florida, before deciding on High Springs. Jerry said he loves the classic cars and 1950s aesthetic.

The couple came over on a business visa.

“Basically, the idea is we buy a business and employ Americans,” he said.

Aside from the American paperwork, a major challenge for the duo has been reversing the reputation of the restaurant.

“The place doesn’t have a good name, if I’m being honest,” he said.

When Floyd’s Diner opened in 2001, it did have a good name. “For the last six years, it hasn’t had any of that,” Jerry said.

The Wakefields are confident they can restore The Diner to its former glory.

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W - Silver Springs gate IMG-20130725-00019OCALA – Silver Springs in Ocala will soon be a completely different park.

The State of Florida, which currently leases the land for Silver Springs to a company that manages it as a private park, will take over management Oct. 1 and incorporate it into the state park system.

In order to transition Silver Springs into a typical state park, some of the features will be removed, said Rick Mercer, director of operations for the Florida Department of Environmental Protection. Activities such as jeep rides and exotic animal displays will be gone, Mercer said, in order to bring Silver Springs more in line with a standard state park.

“The mission of the Florida park system is to provide resource-based recreation while preserving, interpreting and restoring natural and cultural resources,” said Matt Mitchell, spokesman for the Florida Park Service. The exotic animals and jeep rides “are not really the more passive elements of recreation that we promote,” Mercer said.

The goal is to get people to enjoy the natural Florida, Mitchell and Mercer said. Some activities, such as the glass-bottom boat rides and kayaking, will still be available for an additional fee.

Renovations will transform the look of the park, they said. Exotic plants that have invaded Silver Springs are being removed. These plants have a negative impact on the native flora, while detracting from the natural look of the park, Mitchell said. “This allows the propagation and spread of natural plant communities that should be there,” Mercer said. Many of the exotic plants are dead and decaying.

The infrastructure will be renovated to conform to the way other state parks look, including paint jobs with more muted tones that blend in better with the natural scenery. Visitors will be able to see the real Florida, Mercer and Mitchell said, with the park better representing the local area.

“The park over time will become more native in its appearance,” Mercer said.

The glass-bottom boats will be stripped apart and rebuilt. Engineering projects to improve drainage systems and water quality will be undertaken.

With the state running the park, Mercer and Mitchell said there would be a bigger focus on conservation and protecting the water quality of Silver Springs.

“A private entity has to make money,” Mercer said, “but the environment is the bottom line to us.”

“I firmly believe that in five years, you’ll see a significant increase to the environmental conditions in the park,” he added.

As a state park, it will cost $5 per person or $8 per vehicle with up to eight people to enter the park. Hours will be from 8 a.m. to sunset, every day of the year. Silver Springs will be combined with Silver State Park to form one entity.

Volunteers and concessioners will play a major role in running Silver Springs, Mitchell said. Canoeing, kayaking and some event planning will be outsourced to third parties.

Residents in the Ocala area have given overwhelmingly positive feedback over the changes, Mercer said.

“I think the local residents are going to be extremely pleased,” he said. Even with some attractions, such as the glass-bottom boats remaining, the main feature for the visitors will be the natural scenery.

“First and foremost, they are going to enjoy the beauty of natural Florida,” Mercer said.

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